Voor degenen die goed Engels kunnen lezen hier een stuk van Dr. Hopf-Seidel over chronische Lyme (2012) dus inmiddels wel verouderd.
Voor degenen die geen goed Engels kunnen lezen, heb alles vertaald op het stuk na van de behandeling helemaal onderaan het artikel dus wil je Nederlands kunnen lezen dan gil maar.
Onderstaand stuk, zoveel mogelijk witregels proberen te maken legt zij uit welke factoren er een rol spelen bij het ontwikkelen van chronische Lyme. http://www.dr-hopf-seidel.de/mediapool/ ... 9-2012.pdf
Known factors, that can lead from an acute Borrelia infection to a chronic one
In completely healthy individuals without previous stress on the immune system, the body`s own
defense system, such as the production of antibodies against Borrelia, can be sufficient to prevent
the onset of further Borrelia-related symptoms.
Epidemiological studies show that out of 100 Borrelia-infected
patients who developed antibodies, only 10 showed clinical signs of the disease. However,
the follow-up observation period for these studies was, in all cases, so short that no definite
conclusions should be made because many Borrelia-related symptoms appear only much later.
This latter opinion is supported by clinical, longtime observations made by Dr. Hassler, M.D., who,
over years, monitored his patients with a confirmed infection of Borrelia. Many of these patients
were seropositive but asymptomatic (such as the “healthy lumberjack” type). Nevertheless, many of
them only first began to show symptoms and complaints of a Borrelia-related disease as late as eight
years after infection.
However, those who begin to show symptoms shortly after infection (such as the “Borreliosis flu”)
are more likely to later suffer from chronic Lyme Disease with its confusing variety of symptoms.
Additionally, this can be dependent on some other risk factors and (genetic) conditions, of which, so
far, we only know a few and for which some new laboratory tests can check.
For those without a really strong immune system, the main reason for the progression to a chronic
course of Lyme disease is the lack of or insufficient treatment with antibiotics at the time when
there was an Erythema migrans, a lymphocytoma or, equally as important as both of these, a
“summer flu” shortly after a tick bite.
It is hard to think of having an infection with Borrelia if there is no known bite by a tick. Yet lately
there are reports of Borrelia transmission to humans by fleas and horseflies. In all of these cases it is
much harder to identify a particular condition as Lyme disease. It should also be noted that Borreliainfections can be transmitted sexually or from mother to child during pregnancy. Even these rare
forms of transmission should be considered when examining a complex yet undiagnosed illness.
Another reason for an inadequate elimination of pathogens could be -as already mentioneda
weakness in the patient’s immune system. This could be due to an inborn lack of immune-
globulin or due to a previous treatment with immunosuppressent medication for another
severe illness, thus inhibiting the body’s ability to defend itself against invading bacteria.
Other factors that increase the risk of developing chronic LD infection are environmental toxins such
as solvents, softeners (phthalates), fungi and heavy metals. These include, to name only a few, lead
(from old pipes), Cadmium (manure, cigarette smoke, waste burning) and nickel (jewelry or food),
as well as aluminum (in deodorants, antacids and in many vaccines where it is used as a stabilizer).
More serious is the toxic load after exposure to dental/medical interventions. Several alloy materials
used by dentists for tooth inlays or crowns (Gold, Palladium etc.) and their “glue” (Methylmethacrylat
or MMA) can contribute to the development of chronic LD.
The worst culprits are amalgam
fillings, since roughly 50% of amalgam is mercury, which is a strong (neuro)toxin. Many vaccinations
can be even toxic for those with an impaired genetic detoxification function for, among others,
heavy metals (for example GST-enzyme deletions or weakened activity of GST-enzymes and SOD 2-
variants). Until recently, many vaccinations (e.g. Twinrix® against Hepatitis B) contained Thiomersal
(in the USA Thimerosal or Phenylmercury) as an antibacterial preservative, as well as AluminiumHydroxide
(Al-OH) as a stabilizer.
This could potentially have very serious consequences, especially
for infants and young children, as their immature nervous and immune systems are often not strong
enough to cope with these powerful neurotoxic substances.
Mercury poisoning primarily affects the peripheral and central nervous system, resulting in
polyneuro-pathic disturbances, as well as psychological and cognitive dysfunctions. Those suffering
from chronic LD often show a Type IV-allergy to amalgam composits (e.g. Mercury (Hg), Methyl-Hg
and Phenyl-Hg and sometimes even tin), even long after the removal of the amalgam fillings. Often,
evidence of mercury can be found in the stool from residual deposits in the body, even though the
patient has not recently consumed any mercury-containing foods such as seafood, especially tuna.
The build-up of the toxic effects of these substances is directly related to the degree to which the
patient can or cannot detoxify them (genetic detoxification dysfunction). There are various genetic
tests available for testing the enzyme activity to check the individual`s potential for detoxification
(stage I or II). Usually, detoxification enzymes of phase II are analyzed for this, such as Glutathione-S
Transferases (GST-M1, GST-T1,GST-S1), SOD2, NAT2 and COMT. Normal functions of these are
needed to excrete heavy metals and solvents. If there is an intolerant reaction, when applying a
normal dose of medicines, it is also recommended to check the phase I enzymes of the Cytochrome
P 450-System (i.e. Cyp 2D6, Cyp 2C19 or Cyp 3 A/4 et.al.) to avoid the risk of incorrect dosing (under
dosing or overdosing according to the metabolizing ability of these enzymes).
Taking this into consideration, it is apparent that many chronic LD patients have, additionally, a
noticeable reduction in their enzyme activity or even a genetic absence (so called deletions) of
certain detoxification enzymes of phase II. This missing ability to detoxify explains the build-up of
heavy metals and also the continuing weakening of the immune system, compromising the patient`s
ability to deal with new pathogens (especially with the persistent intracellular ones, such as the
However, in the author`s experience, the immune system can improve and become more effective
again after detoxification, through certain supplements and herbal medicines.
(see Vitamin and mineral supplementation p. 24 ff)
Heavy metals, like so many other toxins, (i.e. pesticides, biocides, and fungi) lead to an increased
accumulation of free radicals. This causes an abnormal metabolic reaction, the so-called nitrit/
peroxynitrite-cycle or better known as NO/ONOO-Cycle (according to Martin Pall, Ph.D.), which leads
to an increased formation of Nitrogen Oxide (e.g. Peroxynitrite, Nitrotyrosine, Nitrophenylaceticacid
just to name a few). This causes nitrosative stress in cells (and also in the immune cells) and therefore
a decrease in immune system function.