The FDA Just Approved the First Test for Mycoplasma Genitalium, a Commonly Misdiagnosed STI
Chlamydia isn't always chlamydia.
By Claire Gillespie
Treatment for M. genitalium isn’t necessarily the same as treatment for chlamydia and gonorrhea.
Although there aren’t currently any guidelines for treating an M. genitalium infection specifically, the CDC treatment guidelines recommend standard antibiotics for people with urethritis, cervicitis, and pelvic inflammatory disease. “When M. genitalium is suspected in people with these disease syndromes, the recommended antibiotic is azithromycin,” Manhart says.
However, she continues, resistance to azithromycin has been documented in some people with M. genitalium. In some places, almost 60 percent of those with the infection show resistance. And the other standard antibiotic for these issues, doxycycline, doesn’t work for everyone either.
Bron: self.com, lees meer
Ik vroeg mij af of antibiotica resistentie kan worden veroorzaakt door aanwezige (en ongediagnosticeerde) co-infecties, iemand?
The potential impact of coinfection on antimicrobial chemotherapy and drug resistance
Ruthie B. Birger,#1 Roger D. Kouyos,#2,3 Ted Cohen,4 Emily C. Griffiths,5 Silvie Huijben,6 Michael J. Mina,1,7 Victoriya Volkova,8 Bryan Grenfell,1,9 and C. Jessica E. Metcalf
The impact of HIV coinfection on drug-resistant TB and malaria, on which recent major strides in research have been made, are classic examples of how an immunosuppressive pathogen can exacerbate resistance problems.
For TB, Dye et al.  suggest several mechanisms for why HIV coinfection increases the risk of drug resistance, including increased mycobacterial burden  (causing an increased risk of de novo resistance mutations), lower fitness thresholds  (allowing the spread of resistant strains with low fitness), and reduced drug absorption of anti-TB drugs in the presence of HIV  (facilitating selection for partially resistant strains).
For malaria, it has been suggested that an HIV-mediated increase in replication of the malaria parasite promotes de novo resistance . Indeed, an increased prevalence of resistant malaria parasites has been found in HIV-positive versus HIV-negative pregnant women . The mechanisms promoting malaria drug resistance in HIV-coinfected hosts are expected to be similar to those promoting TB drug resistance in HIV–TB infections, but evidence is largely lacking.
Bron: NCBI, lees meer