Depressie: een allergische reactie of infectie?

[Sproetje]

Het valt me op dat ik nu ik de juiste antibioticum gebruik ineens veel aardiger ben voor mijn omgeving.
Ik kan weer lachen, en dat is echt heel lang geleden dat ik dat kon.
Toen vroeg ik me af:
Kun je door aanhoudende infecties depressief raken?

En ik vond iets op medscape

http://www.medscape.com/viewarticle/838376

Pauline Anderson
January 19, 2015

Depression: Allergic Reaction? Infectious Disease?

Researchers are exploring exciting lines of evidence suggesting that depression is not simply an imbalance of neurochemicals in the brain but possibly fallout from an inflammatory response mounted by the body to deal with stress.

Dr Scott Russo
Investigators at the Icahn School of Medicine at Mount Sinai, in New York City, recently linked differences in the peripheral immune system in a mouse model to susceptibility to social stress, findings they correlated with serum cytokine levels in patients with treatment-resistant depression.
Other experts go a step further and promote the idea that the inflammatory state underlying depression may be caused by a pathogen such as a parasite, bacterium, or virus.
This evolving research thrust could have huge implications for depression treatment. It could change an almost totally symptom-based paradigm into one based more on biology.

Biology-Based Diagnosis
"It means that clinicians should start diagnosing based on biology and not on behavioral symptoms," said Scott Russo, PhD, associate professor of neuroscience, Icahn School of Medicine at Mount Sinai, told Medscape Medical News.
Dr Russo led the research team that carried out the mouse experiments, the results of which were published online October 20 in the Proceedings of the National Academy of Sciences.

After drawing blood from experimental mice and checking for levels of interleukin 6 (IL-6), researchers put the rodents separately into the cage of a larger, more aggressive mouse, allowing physical contact for 10 minutes a day for 10 days.
Some mice showed symptoms similar to those found in depressed patients, such as social avoidance.
"The mice also no longer preferred sugar water and didn't want to have sex, and it took more to stimulate them in terms of the pleasure centers in the brain," first author of the article, Georgia Hodes, PhD, postdoctoral researcher in neuroscience, Icahn School of Medicine, told Medscape Medical News.
"These animals were in a state that seems to be somewhat similar to depression."
What separated these mice from those that did not develop these symptoms were differences in the peripheral immune system. Even before they were put into the stressful situation, these susceptible mice had more white blood cells than those that were resilient.

Dr Georgia Hodes
"When we stimulated those white blood cells, they released more IL-6, and it predicted which animals would go on to become susceptible and which would go on to become resilient," said Dr Hodes.
Continue Reading

Dr. Brain Fallon heeft er ook iets over geschreven:

http://asp.cumc.columbia.edu/psych/askt ... .asp?SI=80

[Karin]

Ik heb geen idee, maar ik kan me wel gewoon voorstellen dat als je aan de juiste medicatie zit, je je beter voelt, misschien wat minder klachten hebt, en daardoor lijkt het me logisch dat je wat positiever en vriendelijker bent, simpelweg omdat je minder slecht bent.

[RoelA]

Je gemoedstoestand wordt zeker beinvloed bij neurologische lyme!
Neurotransmitters raken van slag en gebieden in de hersenen raken ontstoken die zaken als angst, kwaadheid, nerveusiteit etc regelen. Gek genoeg zijn het altijd negatieve zaken die versterkt worden. Je zult nooit een patient zien die spontaan lachaanvallen of extreme euforie ervaren (althans ik ben ze nog niet tegengekomen).

Voor mij speelden deze symptomen een grote rol bij het ziekteproces, en nog steeds ondervind ik er nu in mindere mate af en toe last van. Depressieaanvallen tot zeer kort durende suicidale overtuigingen, woedeaanvallen, spontaan uitbarsten in huilen (en niet weten waarom), nerveusiteit, ik heb het allemaal mogen ervaren. De juiste behandeling kan hierbij zeker verlichting geven. Feitelijk alles wat het immuunsysteem doet kalmeren heeft een direct positief effect op de gemoedstoestand. Dus ook antibiotica die borrelia doet verminderen (of direct ontstekingsverlagend werkt bijv).
Ik had de grootste moeite met Atovaquon/Mepron en de zogenaamde "Mepron Blues" (google er voor de grap eens op). Dit is een verschijnsel bij een deel van de lymepatienten waarbij het gebruik van Atovaquon/Mepron leidt tot extreme huilbuien en psychische problemen, vaak korte maar zeer heftige episodes. Persoonlijk denk ik dat dit te maken heeft met hoe het middel je immuunsysteem verschuift naar een actievere toestand, iets wat positief werkt voor sommigen, negatief voor anderen.

Dus ja, depressie is niet alleen het gevolg van alleen maar in een ziek-zijn situatie zitten, maar ook door de invloed van de bacterieen en je immuunsysteem op het functioneren van je hersenen.

[Sproetje]

Gek genoeg zijn het altijd negatieve zaken die versterkt worden. Je zult nooit een patient zien die spontaan lachaanvallen of extreme euforie ervaren (althans ik ben ze nog niet tegengekomen).

Nee, ben ik ook nog niet tegengekomen, maar ik dacht meteen aan Mozart en zijn rare hysterische lachjes, ik dacht dat hij leed aan syfilis
Maar ik kan er online niet veel over vinden.
Toevallig zag ik wel deze:

https://www.ncbi.nlm.nih.gov/pubmed/18609421

Abstract
OBJECTIVE:
To examine in a pilot study inappropriate crying and laughing (also termed pseudobulbar affect (PBA)) and underlying mood disturbances in a large clinic based population of Parkinson's disease and movement disorder patients.
.......
75.7% (28/37) had pathological 'crying', 13.5% (5/37) had pathological 'laughing' and 10.8% (4/37) had both.

Okee, dat gaat dan over parkinson, maar ook bij parkinson patienten komt hetzelfde voor als bij lymepatiënten, zoals "cell death" en "neuronal damage" :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570132/

Cytokines, chemokines, other immune mediators, as well as glial and neuronal apoptosis have been documented to play a major role in inflammatory neurodegenerative diseases such as Alzheimer’s disease, AIDS dementia,65 and Parkinson’s disease66 in humans

Ik hoop dan niet dat dit ook op mij slaat
Ik denk het niet want het is niet echt hysterisch te noemen zoals ik lach, het is meer dat ik af en toe weer vreugde kan voelen.

[wombat]

Depressies kunnen een uiting zijn van lyme. Dat werd zelfs door mijn arbeidsgeneesheer lang geleden gemeld. De beste remedie was gaan werken volgens hem. Daar had hij toen nog gelijk in, tot ik andere klachten kreeg.

Ik krijg nu in de borrelia 4 wekencyclus hevige depressieve verschijnselen die enkele dagen duren. Ik heb mij voorgenomen om mij die dagen op te sluiten en geen akties te ondernemen. Ik ben sinds kort 's avonds depressief. Dat is kenmerkend voor een winterdepressie, maar de winter is voorbij en ik heb het nog. Bij een klassieke klinische depressie ben je vooral 's morgens depressief. Bij een gewone depressie ben je de hele dag depressief.

Hier en daar hoor je ook de biologische psychiatrie, die menen dat een klinische depressie een biologische oorzaak heeft. Denken we maar aan lupus: daar wordt allang aanvaard dat hun zware depressies veroorzaakt zijn door hun ziekte.

[VerlorengezondheidM]

Het lijkt mij een infectie, temeer je 'mood swings' zo verbeteren na inname van de AB, maar ik ben geen arts natuurlijk.

Gut Bacteria Spotted Eating Brain Chemicals

GABA, or Gamma-aminobutyric acid, is a neurotransmitter that sends chemical messages through the brain and the nervous system and is involved in regulating communication between brain cells; its role is to inhibit or reduce the activity of the neurons or nerve cells. And it turns out that a recently discovered type of gut bacteria, KLE1738, love it. Well, they love to “eat” it.

In 2016, Philip Strandwitz and his colleagues at Northeastern University in Boston found that they could only grow KLE1738 if they gave it GABA- nothing else made it grow. But why is this important?

From the article:

“Bacteria have been discovered in our guts that depend on one of our brain chemicals for survival. These bacteria consume GABA, a molecule crucial for calming the brain, and the fact that they gobble it up could help explain why the gut microbiome seems to affect mood.

GABA acts by inhibiting signals from nerve cells, calming down the activity of the brain, so it’s surprising to learn that a gut bacterium needs it to grow and reproduce. Having abnormally low levels of GABA is linked to depression and mood disorders, and this finding adds to growing evidence that our gut bacteria may affect our brains.”

Thanks to an experiment in 2011 which showed Lactobacillus rhamnosus could dramatically alter GABA activity in the brains of mice as well as influence how they respond to stress (and using what his team learned), Strandwitz is now looking for other bacteria in the gut that consume or produce GABA. It’s hoped that testing the effects on the brains and behaviors of animals could lead to new treatments for depression or anxiety.

For more information about your gut, check out the video below:


Source: New Scientist

Bron: http://www.healthnutnews.com/gut-bacter ... chemicals/

[Sproetje]

New-Onset Panic, Depression with Suicidal Thoughts, and Somatic Symptoms in a Patient with a History of Lyme Disease

Amir Garakani 1 , 2 , 3 , * and Andrew G. Mitton 4
2015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397473/

The patient was a 37-year-old employed man who self-presented to the emergency department complaining of severe anxiety and suicidal ideas. For 3 months he had been experiencing palpitations, tremulousness, chest pressure, choking sensation, and an intense fear of dying. These symptoms would last for hours. He began seeing a psychiatrist 2 months prior and was started on sertraline that was titrated up to 200 mg a day, along with clonazepam 0.5 mg as needed (he was taking around 1-2 mg a day on average). The patient experienced minimal relief of his symptoms despite these therapies.
[.....]
with a 10-pound weight loss during the previous 2 months.
[.....]
He had a positive Lyme ELISA antibody at that time from a local hospital laboratory. He had been treated with doxycycline 100 mg twice daily for 3 weeks. Besides some occasional mild headaches he had an almost 2-year cessation in symptoms until he began developing muscle aches, spasms, fatigue, and worsening anxiety in the past 2 months.
[.....]
He reported having presented to the ER multiple times for his anxiety and neuromuscular complaints but that an ELISA Lyme antibody test, from 3 weeks prior, had been negative (no Western Blot was sent since the ELISA was negative), as was the rest of his medical workup.
[.....]
His Lyme Western Blot was negative (fewer than 5 out of 10 of the following IgG bands: 18, 23, 28, 30, 39, 41, 45, 58, 66, or 93 kDa; fewer than 2 of the following IgM bands: 23, 39, or 41 kDa), and other blood work, including a comprehensive metabolic panel, CBC, TSH, RPR, Vitamin B12, Folate, ESR, ANA, and CRP, was all negative or within normal limits
[.....]
The patient contacted the hospital's outpatient clinic 9 months after discharge to arrange reinstitution of care. He states that after discharge he visited multiple internists and neurologists and had several ELISA Lyme tests which were negative and Western Blots which were also negative for the required IgM and IgG bands (see above). He then traveled to a specialist in another state who sent blood work to IGeneX Laboratories, Inc., in California, which came back positive for Borrelia and Babesiosis on Bands 31 and 34 for IgG. In addition, he reported that his CD57 count was low (352). He was begun on a 6-month course of oral antibiotics including 3 months of tetracycline and 3 months of azithromycin and fluconazole. At that time, his brain MRI with and without contrast was negative for any white matter or other changes or disease. The patient denied further cognitive deficits since his antibiotic treatment. Patient attempted to have neuropsychological testing and functional imaging but this was not covered by his insurance and he could not obtain them due to the cost.
[.....]

[Sproetje]

Can Psychological Depression Be Triggered By Infections?


https://www.peoplespharmacy.com/2016/10 ... nfections/

[VerlorengezondheidM]

Finally, I’ve found what caused my brain fog, chronic fatigue, depression and aching joints...an insect bite!

‘Ninety per cent of those we see from the UK have been misdiagnosed with burnout or depression. They get passed from one specialist to another, and their condition just gets worse.’

But often the most debilitating symptoms are caused not by the Borrelia, but by the cocktail of co-infections, including chlamydia from the same tick bite. On top of that, it seems Borrelia can weaken the immune system and reactivate dormant viruses.

Bron: Dailymail lees meer.