Borrelia Miyamotoi

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Roxy
Berichten: 5588
Lid geworden op: Wo 29 Okt 2014, 12:14

Re: Borrelia Miyamotoi

Berichtdoor Roxy » Zo 29 Nov 2020, 20:57

@VerlorengezondheidM, aanvullende informatie bij Bron viewtopic.php?f=6&t=1492&start=50#p26570

BMJ Case Reports
14 februari 2013
Case study - 'Seronegative lyme neuroborreliosis in a patient using rituximab' by Willemijn Alexandra van Dop, Marie-José Kersten, Bob de Wever, and Joppe Willem Hovius; Bron https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604215/
Abstract
A 66-year-old woman presented with severe shooting pains throughout her back and legs, followed by progressive deafness, weight loss and headache. She had a history of marginal zone B-cell lymphoma stage IV-B, for which she was successfully treated with immunochemotherapy and rituximab maintenance therapy. A relapse was suspected, but chemotherapy was not administered, since, despite elaborate investigations, malignancy could not be proven. Because of a history of tick bites she was tested for antibodies against Borrelia burgdorferi in serum and cerebrospinal fluid (CSF), which were negative. However, a B burgdorferi PCR on CSF came back positive. The patient was treated for seronegative Lyme neuroborreliosis with ceftriaxone intravenously and dramatically improved. This case presentation demonstrates that, in immunocompromised patients, it is important not to solely rely on antibody testing and to use additional diagnostic tests to avoid missing or delaying the diagnosis.
Outcome and follow-up
During these 3 weeks she improved dramatically, which further strengthened the diagnosis. She gained weight, the complaints of headache and vertigo disappeared and her hearing loss slowly improved. Paired serology on blood and CSF 7 weeks later still revealed no antibodies against B burgdorferi.

One-and-a-half years later, a routine MRI of the myelum showed no evidence for relapse of the lymphoma and the hearing ability had completely returned. During neurological follow-up the patient reported a slight unsteadiness of gait, which was attributed to residual postinfectious complications. The rituximab maintenance therapy had been discontinued during her hospital admission, but despite the slow repopulation of B-lymphocyte subsets, 1.5 years after her initial presentation, there were still no antibodies against B burgdorferi (figure 3).
Discussion
In conclusion, this case report is an important reminder of the fact that in patients treated with drugs such as rituximab, which interfere with the immune response, serological diagnostics are not always reliable. In immunocompromised patients with a high suspicion of infectious diseases, such as infection with B burgdorferi, it is therefore important not to rely solely on antibody testing but to use several additional diagnostic tests (e.g, PCR and culture) to avoid missing or delaying the diagnosis. Lyme neuroborreliosis, although sometimes easy to diagnose, can be difficult to diagnose, and when the clinical suspicion is high, like in our case, additional diagnostic tests or sometimes even empiric treatment should be considered.
De Lyme (neuroborreliose) patiënte is succesvol behandeld met ceftriaxone.
~ I may not be there yet, but I'm closer than I was yesterday ~
~ The people who are meant to be in your life are the ones who know how to gently wait for you to heal ~
~ So encourage each other and build each other up - Positive connections ~

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VerlorengezondheidM
Berichten: 2341
Lid geworden op: Za 19 Sep 2015, 23:59
Locatie: Tilburg
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Re: Borrelia Miyamotoi

Berichtdoor VerlorengezondheidM » Ma 14 Dec 2020, 19:17

Is It Lyme Disease or Tick-Borne Relapsing Fever (TBRF)?

Bron: YouTube (IGeneX Inc.), kijk en luister meer
Lyme Test Negative?
It Still May Be Lyme Disease!

Na 19 jaar onbehandeld rondlopen met een klinisch ziektebeeld: Chronische Lyme, Q-koorts, Bartonella, Babesia, Anaplasma, Chlamydia, Mycoplasma, Rickettsia, Yersinia, Coxsackie A16+ B, HHV-6.

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VerlorengezondheidM
Berichten: 2341
Lid geworden op: Za 19 Sep 2015, 23:59
Locatie: Tilburg
Contact:

Re: Borrelia Miyamotoi

Berichtdoor VerlorengezondheidM » Zo 27 Dec 2020, 21:47

LGLC Living Lands Series 2020: Lyme and tick-borne diseases


Professor Holly Ahern, Associate Professor of Microbiology, SUNY Adirondack

Bron: YouTube, kijk en luister meer

P.S.; hoor ik dat nou goed dat een Borrelia Miyamotoi besmetting door de Ixodes teek niet wordt geassocieerd met een rash of ben ik soms abuis?
Lyme Test Negative?
It Still May Be Lyme Disease!

Na 19 jaar onbehandeld rondlopen met een klinisch ziektebeeld: Chronische Lyme, Q-koorts, Bartonella, Babesia, Anaplasma, Chlamydia, Mycoplasma, Rickettsia, Yersinia, Coxsackie A16+ B, HHV-6.

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VerlorengezondheidM
Berichten: 2341
Lid geworden op: Za 19 Sep 2015, 23:59
Locatie: Tilburg
Contact:

Re: Borrelia Miyamotoi

Berichtdoor VerlorengezondheidM » Di 29 Dec 2020, 01:18

The Complement Binding and Inhibitory Protein CbiA of Borrelia miyamotoi Degrades Extracellular Matrix Components by Interacting with Plasmin(ogen)


Ngoc T. T. Nguyen1, Florian Röttgerding1, Gayatri Devraj1, Yi-Pin Lin2, Arno Koenigs1,3 and Peter Kraiczy1*

Bron: Frontiersin, lees meer
Lyme Test Negative?
It Still May Be Lyme Disease!

Na 19 jaar onbehandeld rondlopen met een klinisch ziektebeeld: Chronische Lyme, Q-koorts, Bartonella, Babesia, Anaplasma, Chlamydia, Mycoplasma, Rickettsia, Yersinia, Coxsackie A16+ B, HHV-6.


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