Vasculitis en Lyme

Wetenschappelijke onderwerpen over Lyme-Borreliose, zoals wetenschappelijke medische publicaties en artikelen die worden ondersteund door dergelijke publicaties. Bij twijfel kies 'Artikelen en Linkjes'.
Sproetje
Berichten: 3109
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Vasculitis en Lyme

Berichtdoor Sproetje » Ma 14 Mei 2018, 17:24

Cerebral vasculitis and intracranial multiple aneurysms in a child with Lyme neuroborreliosis

Elisa Kortela,1,* Jukka Hytönen,2 Jussi Numminen,3 Margit Overmyer,4 Harri Saxen5 and Jarmo Oksi6
2017

http://www.microbiologyresearch.org/doc ... F8AD3CDEBB

Case presentation.
We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B. burgdorferi. Brain magnetic resonance imaging revealed widespread enhancement of the leptomeninges, cranial nerves and artery walls compatible with vasculitis and disturbances in cerebrospinal fluid (CSF) circulation. The patient was treated with ceftriaxone for 2 weeks. Two years later, the patient had an ischemic stroke. Brain magnetic resonance angiography revealed multiple aneurysms, which were not present previously. The largest aneurysm was operated rapidly. The patient was treated with another course of intravenous ceftriaxone for 4 weeks and pulse therapy with corticosteroids. He recovered well.

Conclusion.
This unique case demonstrates complications of LNB that can result in serious morbidity or even mortality. Lumbar puncture and analysis should be considered for paediatric patients with epileptic seizures or cerebrovascular events living in a Lyme borreliosis endemic area.

Henriëtte
Berichten: 1561
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Vasculitis en Lyme

Berichtdoor Henriëtte » Zo 29 Jul 2018, 08:00

Vaskulitische Neuropathie;

Bei Verdacht auf (para)infektiöse Vaskulitis sollten Borrelien-, Cytomegalie-, HIV- und Hepatitis B/C- Titer in Serum und Liquor bestimmt werden, bei VZV-Verdacht PCR-Analyse im Liquor.


Sekundäre systemische Vaskulitiden
Bei Kollagenosen rheumatoide Arthritis
Lupus erythematodes
Sjögren-Syndrom
Sklerodermie (selten)
Bei Infektionen (para)infektiöse Vaskulitis (z. B. Lyme-Borreliose, CMV)
chronische Hepatitiden (Hepatitis B/C)
retrovirusassoziierte Vaskulitis
Bei malignen Erkrankungen lymphoproliferative Erkrankungen, Karzinome
Medikamenteninduziert Propylthiouracil, Hydralazine, PenicillamineThalidomid, Valcyclovir und Infliximab


Häufigkeit der vaskulitisassoziierten Neuropathie
Diagnose Häufigkeit der assoziierten Neuropathie
Riesenzellarteriitis 14% (Caselli et al. 1988)
Takayasu-Arteriitis selten (Kissel u. Mendell 1992)
Polyarteriitis nodosa 50-75% (Moore u. Cupps 1983, Olney 1992, Rosenbaum 2001)
Vaskulitis assoziiert mit Hepatitis B/C 19% bei Hepatitis B (Said 1995)
bis zu 50% bei Hepatitis C mit Kryoglobulinämie (Nemni et al. 2003)
Kawasaki-Syndrom selten
Wegener-Granulomatose 11-40% (de Groot et al. 2001, Nishino et al. 1993)
Churg-Strauss-Syndrom 50-75% (Chumbley et al. 1977, Olney 1998, Rosenbaum 2001)
Mikroskopische Polyangiitis 50-75% (Chumbley et al. 1977, Olney 1998, Rosenbaum 2001)
Schoenlein-Henoch-Purpura nicht beschrieben
Essentielle kryoglobulinämische Vaskulitis 7-60% (Garcia-Bragado et al. 1988, Gemignani et al. 1992)
Kutane leukozytoklastische Vaskulitis nicht beschrieben
Rheumatoide Arthritis mit Vaskulitis 1-21,5% (Chalk et al. 1993, Peyronnard et al. 1982, Said 1995)
40-75% (Cruickshank 1954, Scott et al. 1981)
Lupus erythematodes 6-21% (Feinglass et al. 1976, Omdal et al. 1993)
Primäres Sjögren-Syndrom 10-23% (Gemignani et al. 1994, Mauch et al. 1994, Mellgren et al. 1989, Molina et al. 1985)
Sklerodermie 14% (Averbuch-Heller et al. 1992, Hietaharju et al. 1993)
HIV-Infektion 2% (Fuller et al. 1993)
Lyme-Borreliose 2% (Halperin et al. 1987, Meier et al. 1989, Schäfers et al. 2001
)
Sarkoidose selten (Said et al. 2002)


https://www.klinikum.uni-muenchen.de/Fr ... uropathie/

Henriëtte

Henriëtte
Berichten: 1561
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Vasculitis en Lyme

Berichtdoor Henriëtte » Zo 30 Dec 2018, 07:08

Cerebrovascular Manifestations of Lyme Neuroborreliosis—A Systematic Review of Published Cases;

in rare cases, it can also lead to cerebrovascular complications. We aimed to perform a systematic review of all reported cases of LNB complicated by central nervous system vasculitis and stroke or transient ischemic attack (TIA).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397664/
Henriëtte


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