Lyme en Sepsis

[Sproetje]

Endotoxinen Tolerantie:

Potayto/Potahto: Post-Sepsis/Immunoparalysis

http://badlymeattitude.com/2015/03/21/p ... paralysis/

I learned something new this week. This little thing we like to call “chronic Lyme” that’s actually post-sepsis syndrome (according to the NIH), is also called “immunoparalysis.” And the really great thing about that is, the research goes back to at least 1980 and ties in “endotoxin tolerance,” which is what happens when your immune system is shut off by the OspA or other fungal-type antigen, and doesn’t recognize (and therefore doesn’t fight) fungal antigens any more.

CDC Officer Alan Barbour was the dude who said OspA “overwhelms” the immune system, when describing what antigenic variation in spirochetes does to humans (US Patent 6,719,983). This is a term you want to remember in case you hear it again: “overwhelmed” immune system means: “turned off.” “Turned off” is the complete opposite of an “inflammatory” or “autoimmune disease.”
(.....)

[Sproetje]

ActionLyme

30-06-2015
http://www.actionlyme.org/POST_LYME_SEP ... SUMMER.htm


Nog meer over sepsis en lyme:

Society for the Advancement of Scientific Hermeneutics
1 Maart 2015

http://www.ohioactionlyme.org/wp-conten ... ndrome.pdf

(....)
We will begin with Lyme disease, or borreliosis, since it is necessary to explain what OspA is, to understand how it fits this fungal model.
(....)

[Sproetje]

Dormant viruses re-emerge in patients with lingering sepsis, signaling immune suppression

Washington Universiteit St. Louis. (Newsroom)
11 Juni 2014

http://news.wustl.edu/news/Pages/27015.aspx

“A controversy has existed over whether patients with sepsis progress to a state of immune suppression,” said co-senior author Gregory Storch, MD, a virologist and chief of the Division of Pediatric Infectious Diseases. “The finding that critically ill patients with sepsis have a number of different viruses circulating in the bloodstream is compelling evidence they are immune-suppressed and dramatically could alter therapy for sepsis.”
[......]
Earlier research at Washington University and other institutions has hinted that lingering sepsis may be linked to immune suppression. But a lack of compelling evidence has kept the debate going.

Surviving Sepsis: Detection And Treatment Advances

Uit: Livescience
18 Augustus 2014

http://www.livescience.com/47387-sepsis ... nigms.html



Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.

Hotchkiss RS, et al
Pubmed 2013

http://www.ncbi.nlm.nih.gov/m/pubmed/24 ... iss+sepsis

Abstract

Sepsis - which is a severe life-threatening infection with organ dysfunction - initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.

[VerlorengezondheidM]

Ik vraag mij af of het toevallig is de Elisa test die gemiddeld 60% van de Lyme patienten mist en onderstaande?

NHS 'underestimates sepsis cases by 70 per cent': Silent killer feared to strike 260,000 patients a year

Sepsis affects 70 per cent more patients than NHS bosses think, a major report will warn today.

Doctors say the findings, which suggest up to 65,000 patients die from sepsis each year, reveal the ‘gravity and sheer scale of the problem’.

Research by the York Health Economics Consortium suggests 260,000 Britons develop the condition every year. This figure is 110,000 higher than previous estimates, which put the number of affected patients at 150,000.

Professor Sir Bruce Keogh, medical director of NHS England, said far more can be done to combat the illness’s ‘terrible toll’.

Sepsis, known as the ‘silent killer’, strikes when a bacterial infection such as septicaemia or blood poisoning sparks a violent immune response, in which the body attacks its own organs.

If antibiotics are given quickly it can be effectively treated.

But sepsis is notoriously difficult to diagnose until it is too late, and kills at least 44,000 patients a year – more than breast, bowel and prostate cancer combined. The latest report suggests deaths may be far higher – but a second study will be launched to clarify this.

Dr Ron Daniels, chief executive of the UK Sepsis Trust, said deaths may be as high as 65,000.

The Daily Mail launched its End the Sepsis Scandal campaign last year to raise awareness of symptoms among patients and staff.

It followed the tragic case of William Mead from Cornwall, who died aged 12 months in 2014 after a catalogue of errors, misdiagnoses and missed opportunities by doctors and NHS helpline staff. In a victory for the campaign in December, Health Secretary Jeremy Hunt announced a major drive to eradicate sepsis.

He promised every new mother would be told about the signs of the condition, announced extra training for doctors and nurses, and said millions of leaflets and posters would be distributed to GP surgeries and A&E units. Hospitals which do not do proper sepsis checks in A&E will lose up to £2million of NHS funds, he said.

Dr Daniels, whose charity commissioned the York report, said Mr Hunt’s actions would save lives. But he added: ‘It is likely that even in the face of these improvements we will still see an increase in the number of deaths compared to previous projections.’

York Health Economics Consortium is an independent think-tank owned by the University of York.

Its report said sepsis costs the UK economy £15.6billion a year, adding that earlier diagnosis and treatment could save more than 14,000 lives annually.

Dr Daniels said: ‘We’ve long been aware that sepsis causes thousands of unnecessary deaths every year and presents an unmanageable economic burden.

‘A crippling paucity of data has thus far confined us to conservative estimates, but the figures reported in YHEC’s study are a shocking new indication of the gravity and sheer scale of the problem. It’s sobering to learn that the issue is so much greater than previously estimated.’

Sir Bruce, who will today host an event in Parliament where the findings will be presented, said: ‘Health professionals are spotting and treating more cases of sepsis than ever before, but there is still more we can do to reduce the terrible toll that this severe and life-threatening condition has on patients and their families.

‘That’s why we are working closely with the UK Sepsis Trust and medical leaders on awareness-raising to ensure that the signs of sepsis are spotted as soon as possible, as well as introducing more measures than ever before to support and equip organisations and health professionals to improve the chances of survival and reduce complications.’

Bron: http://www.dailymail.co.uk/health/artic ... -cent.html

[VerlorengezondheidM]

Hoewel ik de antibiotica visie niet deel van Beaux Reliosis (Borreliosis ) omdat ik denk dat een vernietiging van Borrelia, co infecties en blebs wel degelijk de klachten doet verminderen, vind ik de essentiële! gebruikte Lymetestmethodieken wel weer interessant

Beaux Car Talk 11/2/2017: The Lyme Testing Scam

Bron: YouTube, kijk en luister meer

Lyme-M.S.I.D.S.-PostSepsis

MSIDS=Multiple Systemic Infectious Disease Syndrom

En ik maar denken dat Lyme en co-infecties een makkelijk op te sporen en eenvoudig te behandelen (maximaal 4 weken laaggedoseerde antibiotica), slechts marginale en zeldzame ziekte is

[Sproetje]

" Hoewel ik de antibiotica visie niet deel van Beaux Reliosis (Borreliosis ) "

Ja, vind ik ook hoor, ik vind er overigens wel meer in staan waar ik het niet helemaal mee eens kan zijn.

Verder heb ik ook regelmatig mijn twijfels bij de OspA van action lyme.
Er wordt gezegd dat het "overwelming" werkt mbt het immuun systeem maw: dat het je immuunsysteem zou stoppen (interpretatie van Beaux Reliosis) , dit onderbouwd door een onderzoek van naar ik dacht: Barbour
Maar ik had nu juist een op hol geslagen immuunsysteem.

[VerlorengezondheidM]

"
Verder heb ik ook regelmatig mijn twijfels bij de OspA van action lyme.

Daar heb ik van meet af aan al mijn twijfels over gehad.

Is het niet zo dat chronische Lyme patienten meerdere soorten Osp's positief hebben?
Ik vind het te simplistisch neergezet en beredeneerd.

Die reactiverende virussen, waardeloze testmethodieken en post sepsis vind ik wel interessant, maar ook ILADS onderzoekt deze invalshoeken.

Ik denk dat ILADS het dichtst bij de waarheid zit, vooral met die (onvermijdelijke?) co-infecties.

Het is ook geen kwestie of chronische Lyme wel of niet bestaat.

De vraag moet naar mijn mening zijn: komt het de maatschappij / VWS financieel gezien wel uit dat chronische Lyme een valide bestaansrecht krijgt of is SOLK goedkoper en makkelijker?

Dankzij (de selectieve?) marktwerking in de zorg zijn ziekenhuizen commerciële instellingen geworden die efficiënt en kostenbesparend moeten werken.

Nederland heeft dit massaal gewild en hierop gestemd tot men zelf......
Chronische Lyme krijgt en buiten de veel te strikte criteria valt, maar dan is het al te laat en is het systeem vastgezet zoals het nu is.

[Henriëtte]

Potential impact on course inflammation and outcome in sepsis and meningitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC118062/

http://citeseerx.ist.psu.edu/viewdoc/do ... 1&type=pdf

Henriëtte

[Henriëtte]

Lyme arthritis presenting as acute septic arthritis in children

There is considerable overlap in the initial clinical and laboratory presentations of acute septic arthritis and Lyme arthritis. The authors present a consecutive case series of 10 children with acute arthritis consistent with septic arthritis who ultimately were diagnosed with Lyme disease. Fifty percent presented with a fever of 38 degrees C or higher. The peripheral white blood cell count and differential were not elevated, but the erythrocyte sedimentation rate and the C-reactive protein were significantly elevated. The joint fluid cell count was elevated, with 91% neutrophils. Seven patients in this series underwent emergent joint irrigation and debridement for presumed septic arthritis. The authors suggest that in regions where Lyme disease is endemic, children who present with presumed septic arthritis should also be evaluated for Lyme disease. The authors also present a protocol for evaluation and management of these diagnostically challenging cases.
Lyme Arthritis Presenting as Acute Septic Arthritis in Children | Request PDF. Available from: https://www.researchgate.net/publicatio ... n_Children [accessed Mar 04 2018].

Henriëtte

[Sproetje]

Chronic septic arthritis caused by Borrelia burgdorferi.
1993

https://www.ncbi.nlm.nih.gov/pubmed/8242938

Vond nog wat algemenere info over sepsis en endotheel

Endothelium function in sepsis
2000

https://link.springer.com/article/10.1007/s000110050579