disulfiram

Voor alle onderwerpen over de behandeling met antibiotica en/of andere reguliere geneesmiddelen.
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Roxy
Berichten: 5956
Lid geworden op: Wo 29 Okt 2014, 12:14

Re: disulfiram

Berichtdoor Roxy » Ma 26 Okt 2020, 12:58

Henriëtte schreef:Disulfiram: Ein Test zur Symptomreduktion bei Patienten mit zuvor behandelter Lyme-Borreliose ;
Wissenschaftler entdeckten kürzlich, dass Disulfiram im Labor wirksam ist, um das zu töten Mikroben, die Lyme-Borreliose verursachen. Disulfiram ist allgemein bekannt als "Antabuse

Die meisten Bemerkenswert ist, dass Disulfiram nicht nur die aktiv replizierende Lyme wirksam abtötete Bakterien (dh diejenigen, die typischerweise durch mehrere Antibiotika abgetötet werden), aber auch die relativ ruhende oder ruhende Lyme-Bakterien (diese werden als "arzneimittelverträgliche Persistenten" bezeichnet) - Diese letzteren Spirochäten sind diejenigen, die für die Entwicklung der chronischen Lyme verantwortlich sein können Krankheitssymptome.

https://ichgcp.net/de/clinical-trials-r ... CT03891667

Ilads 2020
11 september 2020
Disulfiram In The Treatment Of Lyme & Babesiosis - Retrospective Review Of First 3 Years' Experience In One Medical Practice
Kenneth B Liegner, MD
BACKGROUND
High throughput screening found disulfiram more potent versus Bb than conventionally recommended antibiotics in vitro(1). This prompted off-label use of this agent as previously reported (2).

AIMS:
We report our subsequent experience with disulfiram between 3-15-2017 and 3-15-2020.

PATIENTS & METHODS:
Patients were evaluated in the ordinary course of clinical care. In addition to standard treatment methods disulfiram was mentioned as a possible option for the treatment of Lyme disease. For those preferring disulfiram, full discussion was held regarding potential risks, potential benefits and considerable uncertainties with novel application of this agent. 4 of 71 patients were 'lost to follow-up' resulting in 67 evaluable patients.

RESULTS:
Of 67 evaluable patients:
13 of 33 patients (39%) who completed one or two courses of high-dose disulfiram (> or = 4 mg/kg/day) were able to enjoy 'enduring remission' defined as remaining clinically well for > or = 6 months without further anti-infective treatment.
62 of 67 patients (92.5%) endorsed net benefit from the received course or courses of disulfiram, combining the low dose group (<4mg/kg/day), the high dose group and the 'cross-over' group.
5 of 67 patients (7.5%) reported either no benefit or unclear benefit from application of disulfiram. It is unclear whether a low dose regimen can yield 'enduring remission' after discontinuation of treatment.
10 of 67 patients (15%) reported development of paresthesias thought consistent with disulfiram-induced peripheral neuropathy. These symptoms completely or substantially resolved over weeks to months with only minimal if any residua in 7 of 10. Mild to moderate residual persisted in 3 of 10.
21 of 67 patients (31%) exhibited emotional instability ranging from hypomania to anxiety and/or depression. Mood disturbance resolved within days to weeks in all patients with cessation of disulfiram although a few required psychiatric intervention.
10 of 67 patients (15%) exhibited mild to moderate hepatic transaminitis which required cessation of treatment in 2 patients. Transaminitis fully resolved in all cases.

CONCLUSIONS:
Disulfiram monotherapy is useful in the treatment of Lyme disease. Regular laboratory monitoring and close clinical follow-up is necessary. Dosages of 4-5 mg/kg/day for 6-12 weeks appear to be optimal for attempting to achieve 'enduring remission' while minimizing adverse effects. Dosages as low as 0.06 - 2 mg/kg/day for indeterminate durations also conferred benefit with minimal adverse effects. An individualized and flexible approach with shared decision-making is particularly suitable in the use of this agent
Het betreft een kleine patiëntengroep van 67 patiënten. Het is onduidelijk of de resultaten blijvend zijn na de beëindiging van de behandeling.
In Lyme patiëntengroepen melden er mensen dat zij moeten stoppen met de behandeling omdat er ernstige bijwerkingen/klachten (neuropathie, hartproblemen, psychische klachten/psychose) ontstaan, de periode van 6-12 weken behandelen niet wordt gehaald, het middel niet goed wordt verdragen bij lage en hoge doseringen, sommigen op de spoed (SEH) in het ziekenhuis terecht zijn gekomen, dat de leverwaarden erg hoog worden. Farmacotherapeutisch Kompas - Disulfiram; Bron https://www.farmacotherapeutischkompas. ... jwerkingen

Frontiers in Medicine
20 April 2020
Alain Trautmann1*, Hugues Gascan2 and Raouf Ghozzi3* - 'Potential Patient-Reported Toxicities With Disulfiram Treatment in Late Disseminated Lyme Disease'; Bron https://www.frontiersin.org/articles/10 ... 00133/full
..However, in a recent talk at the 2019 ILADS Symposium, Dr. Liegner presented data on 30 Lyme Disease patients that he had treated with DSF. In 18 of them, DSF provoked either peripheral neuropathies or psychiatric problems, or both.

..It is necessary to understand why DSF toxicity appears particularly severe and frequent in patients with Lyme Disease, and to rapidly explore the reasons for such DSF toxicity in Lyme Disease animal models. Until we have the first answers to this question, it would be premature to consider DSF as the new miracle molecule for patients suffering from late disseminated Lyme Disease..

..The conclusions are: 13 out of 16 patients experienced DSF-induced toxic or side effects, mainly concerning the nervous system (neuropathies, headaches, dizziness, difficulty of concentration and expression, sleep disturbance, general pain increase, increase in general fatigue). Several patients reported a more specific increase in their osteo-articular pains, nausea or intestinal disorders..

..However, some patients, who had already experienced Jarisch Herxheimer reactions before, reported that some of the reactions encountered with DSF treatment were clearly of a different nature. Collectively, these observations suggest that patients with persistent Lyme Disease are more sensitive to the toxicity of DSF than people who have been treated for alcohol dependence, and that in these patients, DSF-induced toxicities are not all related to Jarish Herxeimer reactions..
~ I may not be there yet, but I'm closer than I was yesterday ~
~ The people who are meant to be in your life are the ones who know how to gently wait for you to heal ~
~ So encourage each other and build each other up - Positive connections ~

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Roxy
Berichten: 5956
Lid geworden op: Wo 29 Okt 2014, 12:14

Re: disulfiram

Berichtdoor Roxy » Di 12 Okt 2021, 22:58

Onderzoek
Initial Study - 'Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease' by Brian A Fallon; Bron https://clinicaltrials.gov/ct2/show/NCT03891667
De resultaten van de pilot-studie (voorlopige studie ter verkenning) met 24 personen zijn uitgesteld naar 31 maart 2022.
..The investigators propose therefore a small 14-week randomized placebo-controlled pilot study enrolling 24 patients with persistent symptoms despite prior antibiotic treatment for Lyme disease (known as Post-treatment Lyme Disease Syndrome). Among the 24 disulfiram-treated patients, half will get 8 weeks of disulfiram and the other half will get a shorter duration of disulfiram for 4 weeks followed by 4 weeks of matching placebo. After week 8, patients will be off pills for 2 weeks for the primary week 10 evaluation and then for another 4 weeks for the week 14 follow-up evaluation. This will be a double-blinded study; neither physician nor patient will know which treatment group the patient is assigned to.

With this initial study, the investigators will be able to evaluate the side effects, tolerability and initial signs of the effectiveness of disulfiram in reducing symptoms among the 24 patients assessed. The results of this study will guide the investigators regarding whether a larger definitive randomized trial should be conducted and which treatment schedule is optimal..

Lymedisease.org
23 november 2020
By Dr Daniel A. Kinderlehrer MD (internist) - Patients can respond very differently to disulfiram. Be cautious (over 100 patients); Bron https://www.lymedisease.org/kinderlehre ... m-caution/

Lymedisease.org
8 februari 2021
Kinderlehrer videos discuss disulfiram treatment, mast cell, and more; Bron https://www.lymedisease.org/kinderlehre ... mast-cell/

8 oktober 2021
dr R.H is bezig met nieuw klinisch onderzoek waarbij er met een lagere dosering wordt behandeld; Bron https://www.facebook.com/drrichardhorowitz/
..We are now doing a new clinical trial combining lower dose DSF with higher dose pulsed dapsone x 4 days (neither DSF or dapsone has significant effects on the microbiome based on clinical experience) or trialing pulsed high dose dapsone. So far, the early clinical results are encouraging. Certain resistant patients are showing significant improvement. I plan on publishing the results at the beginning of next year once enough patients have enrolled and I see the long term efficacy. Stay tuned, but in my world, we are getting closer and closer to finding a durable regimen for long term remission..
~ I may not be there yet, but I'm closer than I was yesterday ~
~ The people who are meant to be in your life are the ones who know how to gently wait for you to heal ~
~ So encourage each other and build each other up - Positive connections ~

Gebruikersavatar
Roxy
Berichten: 5956
Lid geworden op: Wo 29 Okt 2014, 12:14

Re: disulfiram

Berichtdoor Roxy » Vr 15 Okt 2021, 22:04

Lyme Disease.org
5 oktober 2021
LYME SCI: My re-cap of recent LDA/Columbia Lyme conference; Bron https://www.lymedisease.org/lda-columbi ... onference/
On October 2, I attended the 21st annual scientific conference put on by the Lyme Disease Association and Columbia University’s Vagelos College of Physicians & Surgeons. The virtual event was entitled Lyme & Other Tick-Borne Diseases: Research for a Cure.
Disulfiram
..Dr. Fallon made a point of stating the use of disulfiram is experimental and not currently approved for Lyme disease..
Een experimentele of verkeerde behandeling kan érg schadelijk zijn voor de gezondheid. Patiënten kunnen als gevolg van de behandeling ernstige langdurige (of blijvende) klachten (neurologische en of psychische) krijgen en of blijvende schade aan de darmen en de werking van het afweersysteem (immuunsyteem) krijgen. Mensen worden in dat geval niet beter maar zieker.

Opmerkelijk is dat dr R.H bezig is met nieuw klinisch onderzoek waarbij er met een lage dosering wordt behandeld; Bron https://www.facebook.com/drrichardhorowitz/
8 oktober2021:..We are now doing a new clinical trial combining lower dose DSF with higher dose pulsed dapsone x 4 days (neither DSF or dapsone has significant effects on the microbiome based on clinical experience) or trialing pulsed high dose dapsone. So far, the early clinical results are encouraging. Certain resistant patients are showing significant improvement.
I plan on publishing the results at the beginning of next year once enough patients have enrolled and I see the long term efficacy. Stay tuned, but in my world, we are getting closer and closer to finding a durable regimen for long term remission..
Forbes
26 februari 2020
Tipping Point: The Resistance Is Gaining In The Lyme Wars; Bron https://www.forbes.com/sites/marybethpf ... 352ee45d5a
Fred Verdult, a longtime activist who was knighted for his work in The Netherlands, exemplifies the problem and progress. He takes one pill daily for HIV infection and has never been ill from AIDS. He has been disabled by, and treated with dozens of pills daily, for Lyme disease. “The contrast with Lyme couldn’t be greater,” he wrote in answer to my survey.

He nonetheless sees a corner turning, in particular in the use of repurposed drugs; Bron https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627205/ that are helping patients like him. “It will take years,” he told me. “But the final result is very clear: In 2030, Lyme and other tick-borne diseases will be considered as normal diseases.”
~ I may not be there yet, but I'm closer than I was yesterday ~
~ The people who are meant to be in your life are the ones who know how to gently wait for you to heal ~
~ So encourage each other and build each other up - Positive connections ~


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