Biofilm

Voor informatie die te maken heeft met Lyme-Borreliose en/of co-infecties in artikelen en linkjes. Zoals youtube-video’s, websites, medische artikelen, blogs, artikelen over lyme en politiek, verouderd lyme-nieuws, etc.
Henriëtte
Berichten: 1640
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Biofilm

Berichtdoor Henriëtte » Vr 13 Sep 2019, 13:01

The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis; 03-12-2018

LNB is, in many cases, responsive to appropriate antimicrobial therapy and the clinical improvement sustained by the antibiotic treatment provide further evidence for the direct contribution of B. burgdorferi in disease pathogenesis. However, the chronic persistence, the frequent reoccurrence of LNB and the ability of B. burgdorferi to tolerate multiple cycles of antibiotic treatment is strongly suggestive for the formation of biofilm or biofilm-like protective structure (20–23). Indeed, different studies have shown that B. burgdorferi can switch from a motile to a stationary status, in which the cells are embedded within a biofilm matrix (22). B. burgdorferi biofilms have been observed both in vitro and in human infected skin tissues (22, 23). These structures express different mucopolysaccharides, particularly alginate, extracellular DNA and calcium, which are all typical markers of biofilm (22). The presence of biofilm may explain the low rate of Borrelia detection in the blood of infected patients as well as the ability of the spirochetes to evade the host immune system and resist the antibiotic therapy (21, 24–27).

This review investigates the differences in the epidemiology and clinical manifestations of LNB with particular emphasis on the pathogenetic role of B. burgdorferi biofilm in tissue adhesion, colonization and survival.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287027/

Henriëtte

Sproetje
Berichten: 3136
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Biofilm

Berichtdoor Sproetje » Vr 13 Sep 2019, 19:17

Biofilm Structures of Borrelia burgdorferi Not Only Display More Tolerance to Lyme Antibiotics But Also Cause More Severe Pathology In a Mouse Arthritis Model: Implications for Understanding Persistence, PTLDS and Treatment Failure

Jie Feng, Tingting Li, Ying Zhang
2018

https://www.biorxiv.org/content/10.1101/440461v2


…..
Here we isolated biofilm-like microcolony and planktopic form (spirochetal forms and round body) from stationary phase culture and found that the stationary phase planktonic form (SP) and microcolony form (MC) were much more tolerant to the current antibiotics for Lyme disease, doxycycline, ceftriaxone and cefuroxime than log phase spirochete form (LOG). In addition, we also compared the ability of the variant forms to cause disease in a mouse arthritis model. Surprisingly, the MC in particular and the SP caused a more severe arthritis with an earlier onset of inflammation and joint swelling than LOG. MC-infected mice showed significant joint swelling as early as 9 days post-infection, while the LOG and SP did not cause significant swelling.
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