Welke antibioticum gaat door de bloed hersenbarrière?

[Sproetje]

Vond iets over Ceftriaxone en Doxy:

Ceftriaxone does not reach the brain when it is not inflamed

http://als-cure.com/antibiotics-als/cef ... the-brain/

Doxycycline does not penetrate the blood brain barrier when there is no inflammation

http://lymemd.blogspot.nl/2013/03/blood ... rrier.html

In typical meningitis with active inflammation, there is a breakdown of the BBB and most antibiotics penetrate.

[Sproetje]

The penetration of doxycycline into CSF.
Andersson H, Alestig K.

https://www.ncbi.nlm.nih.gov/pubmed/1070143

Abstract
After single oral or intravenous doses of doxycycline the concentrations found in the spinal fluid did not exceed 0.1 mcg/ml. Daily oral administration for 2-10 days gave a level in the spinal fluid of 0.1-0.76 mcg/ml. The mean value, 0.37 mcg/ml, corresponded to 14% of the concentrations found in serum. Further studies of the penetration of doxycycline in patients with a damaged blood-brain barrier should be performed before doxycycline can be recommended for the treatment of CNS-infections.

[Sproetje]

Hoe lang zou het duren voordat de BBB doorlaatbaar wordt voor de meeste ab's na een erythema migrans?

[Henriëtte]

Nog geen idee Sproetje, na lang zoeken... vind weinig info, het zou me wel benieuwen.

Henriëtte