Dementie in 2040 doodsoorzaak nummer 1

Voor algemene onderwerpen over gezondheid die niet te maken hebben met Lyme-Borreliose.
Sproetje
Berichten: 3121
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Dementie in 2040 doodsoorzaak nummer 1

Berichtdoor Sproetje » Wo 19 Dec 2018, 15:31

CASE REPORTS

Lyme-Associated Parkinsonism: A Neuropathologic Case Study and Review of the Literature

David S. Cassarino, MD, PhD, Martha M. Quezado, MD, Nitya R. Ghatak, MD, and Paul H. Duray, MD
2003
Uit:
ARCHIVES
of Pathology and Laboratory Medicine


http://www.archivesofpathology.org/doi/abs/10.1043/1543-2165(2003)127%3C1204:LPANCS%3E2.0.CO;2

Abstract
Neurological complications of Lyme disease include meningitis, encephalitis, dementia, and, rarely, parkinsonism. We present a case of striatonigral degeneration, a form of multiple system atrophy, in Lyme-associated parkinsonism. A 63-year-old man presented with erythema migrans rash, joint pains, and tremors. Serum and cerebrospinal fluid antibodies and polymerase chain reaction for Borrelia burgdorferi were positive. Clinical parkinsonism was diagnosed by several neurologists. Despite treatment, the patient continued to decline, with progressive disability, cognitive dysfunction, rigidity, and pulmonary failure. At autopsy, the brain showed mild basal ganglia atrophy and substantia nigra depigmentation, with extensive striatal and substantia nigral neuronal loss and astrogliosis. No Lewy bodies were identified; however, ubiquitin-positive glial cytoplasmic inclusions were identified in striatal and nigral oligodendroglia. There were no perivascular or meningeal infiltrates, the classic findings of neuroborreliosis. To our knowledge, this is the first report of striatonigral degeneration in a patient with B burgdorferi infection of the central nervous system and clinical Lyme-associated parkinsonism.

Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Dementie in 2040 doodsoorzaak nummer 1

Berichtdoor Henriëtte » Wo 19 Dec 2018, 15:46

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

Where spirochetes have been found in the brains of Alzheimer’s disease (AD), it may be considered an infectious disease; this is the first and most important consideration [1, 2]. It is also a chronic disease, a biofilm-associated disease, [3] and an autoimmune disease [4]. Further, it is a debilitating disease, a socially-destructive disease, an exceedingly expensive disease, and, lastly, a deadly disease [5]. This review will focus on the biofilm portion of the disorder as well as the autoimmune response. It will also touch on some rational therapeutic concepts for this most irrational of diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008232/

Henriëtte

Sproetje
Berichten: 3121
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Dementie in 2040 doodsoorzaak nummer 1

Berichtdoor Sproetje » Do 20 Dec 2018, 19:15

Cystic borrelia in Alzheimer’s disease and in non-dementia neuroborreliosis


https://www.alzheimersanddementia.com/a ... 52-5260(06)03848-9/fulltext


Background: A cystic form for Borrelia burgdoferi (Bb) was initially reported in 1988 in an autopsy study of Alzheimer’s disease tissue obtained from Dr. George Glenner’s brain bank. Cystic profiles were documented with silver stains, and with Murine Monoclonal antibodies to a Flagellin Epitope specific for Bb and B. hermseii [H9724 from Dr Alan Barbour]. Objective(s): Fresh frozen hippocampus tissues from Alzheimer’s disease cases provided by the Harvard University McLean Hospital brain bank were cultured in BSK M medium to attempt to grow spirochetes in vitro.
Methods: Triturated fresh hippocampus was cultured in vitro in sterile BSK M liquid media at 24 degrees C for one year. Darkfield microscopy examination and Acridine orange staining with epifluorescence microscopy was completed. Detection of specific Flagellin DNA sequences from ORF BBO147 using a Molecular Beacon DNA probe was used to measure incremental increases in Borrelia specific Flagellin DNA in cultures, as compared with the original fresh tissue retained uncultured DNA Extracts. Results: Cystic borrelia structures were recovered from in vitro cultures of fresh Alzheimer disease hippocampus tissue. Incremental increases in Borrelia burgdorferi flagellin B DNA were documented in cultured tissues.
Conclusions: A subset of Alzheimer’s disease is related to chronic Neuroborreliosis in the human host

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VerlorengezondheidM
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Lid geworden op: Za 19 Sep 2015, 23:59
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Re: Dementie in 2040 doodsoorzaak nummer 1

Berichtdoor VerlorengezondheidM » Vr 07 Jun 2019, 16:40

Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study.


Chen CK, et al. Alzheimers Res Ther. 2017.

Abstract

BACKGROUND: Although recent short-term cross-sectional studies have revealed that chronic periodontitis (CP) may be a risk factor for increased cognitive impairment in patients with Alzheimer's disease (AD), systematic reviews and long-term longitudinal studies have provided less clear evidence regarding the relationship between CP and AD. Therefore, we conducted a retrospective cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan to determine whether patients with CP are at increased risk of developing AD.

METHODS: We conducted a retrospective matched-cohort study using the NHIRD of Taiwan. We identified 9291 patients newly diagnosed with CP between 1997 and 2004. A total of 18,672 patients without CP were matched to the patient cohort according to sex, age, index year, co-morbidity and urbanisation level. Cox proportional hazards regression analyses were performed to evaluate the subsequent risk of AD.

RESULTS: Patients with CP had a higher prevalence of hyperlipidaemia, depression, traumatic brain injury and co-morbidities, as well as higher urbanisation levels, than those in the unexposed cohort (all p < 0.01). At the final follow-up, totals of 115 (1.24%) and 208 (1.11%) individuals in the CP exposed and unexposed groups, respectively, had developed AD. Patients with 10 years of CP exposure exhibited a higher risk of developing AD than unexposed groups (adjusted HR 1.707, 95% CI 1.152-2.528, p = 0.0077).

CONCLUSIONS: Our findings demonstrate that 10-year CP exposure was associated with a 1.707-fold increase in the risk of developing AD. These findings highlight the need to prevent progression of periodontal disease and promote healthcare service at the national level.


Bron: NCBI
Lyme Test Negative?
It Still May Be Lyme Disease!

Na 19 jaar onbehandeld rondlopen met een klinisch ziektebeeld: Chronische Lyme, Q-koorts, Bartonella, Babesia, Anaplasma, Chlamydia, Mycoplasma, Rickettsia, Yersinia, Coxsackie A16+ B, HHV-6.

Sproetje
Berichten: 3121
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Dementie in 2040 doodsoorzaak nummer 1

Berichtdoor Sproetje » Di 13 Aug 2019, 18:56

Borrelia in the Brains of Patients Dying With Dementia
Alan B. MacDonald, MD
1986

https://jamanetwork.com/journals/jama/a ... act/362744

I have identified spirochetes in serial subculture of autopsy brain tissues from two patients with dementia. Indirect immunofluorescence, using monoclonal antibodies specific for Borrelia species, resulted in fluorescence of spirochetes that had previously been identified by darkfield microscope examination (Figs 1 through 4).Case 1 was a 74-year-old woman with mild dementia of less than one year's duration. She had resided in New York and Florida. Case 2 was a 69-year-old man who died in a nursing home in Texas after a four- to five-year history of progressive dementia. Parkinsonian symptoms were noted during his last year of life. Neither patient had symptoms of the skin, joint, or cardiac disorders described in Borrelia burgdorferi infection.Recent reports have described patients with various chronic degenerative neurological disorders whose blood or cerebrospinal fluid contains antibodies against B burgdorferi.1 Individuals with cognitive impairment or memory disorders are found within
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