Jarisch-Herxheimer reactie

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Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Jarisch-Herxheimer reactie

Berichtdoor Henriëtte » Ma 31 Dec 2018, 16:25

Jarisch–Herxheimer reaction

a reaction to endotoxin-like products released by the death of harmful microorganisms within the body during antibiotic treatment. Efficacious antimicrobial therapy results in lysis (destruction) of bacterial cell membranes, and in the consequent release into the bloodstream of bacterial toxins, resulting in a systemic inflammatory response.

It resembles bacterial sepsis and can occur after initiation of antibacterials, such as mild silver protein, penicillin or tetracycline, for the treatment of louse-borne relapsing fever (80–90% of patients) and in tick-borne relapsing fever (30–40%). It usually manifests within a few hours of the first dose of antibiotic as fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation with flushing, myalgia (muscle pain), exacerbation of skin lesions and anxiety. The intensity of the reaction indicates the severity of inflammation. Reaction commonly occurs within two hours of drug administration, but is usually self-limiting. It is observed in 50% of patients with primary syphilis and about 90% of patients with secondary syphilis.

The Jarisch–Herxheimer reaction is traditionally associated with antimicrobial treatment of syphilis.[2] The reaction is also seen in the other diseases caused by spirochetes: Lyme disease, relapsing fever, and leptospirosis.[3] There have been case reports of the Jarisch-Herxheimer reaction accompanying treatment of other infections, including Q fever, bartonellosis, brucellosis, trichinellosis, and African trypanosomiasis


https://en.wikipedia.org/wiki/Jarisch%E ... r_reaction

Henriëtte

Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Jarisch-Herxheimer reactie

Berichtdoor Henriëtte » Ma 31 Dec 2018, 16:45

The Jarisch–Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis

Inflammatory substances in spirochetes.

Clinical observations of patients with the JHR suggested a role for endotoxin,57–59 but experimental studies showed that spirochetes do not have biologically active endotoxin as defined by the limulus test.60–63 Substances other than endotoxin as well as mechanisms were described.64–71 In Treponema pallidum, lipoproteins were identified as likely responsible for inflammatory signs because they stimulate macrophages to produce tumor necrosis factor (TNF).64 In Borrelia Burgdorferi, the outer surface protein A lipoprotein stimulates cells in culture to produce transcription factors for cytokines.65 Borrelia recurrentis from human plasma was also negative for endotoxin by the limulus test but was pyrogenic in rabbits.66 The nonendotoxin pyrogen could be the same as the lipoprotein. Lipoprotein of the outer membrane proteins of leptospires caused inflammation in mouse kidney cells.67


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239707/

Henriëtte

Sproetje
Berichten: 3121
Lid geworden op: Di 28 Okt 2014, 20:33

Re: Jarisch-Herxheimer reactie

Berichtdoor Sproetje » Wo 02 Jan 2019, 16:58

Transient worsening of optic neuropathy as a sequela of the Jarisch-Herxheimer reaction in the treatment of Lyme disease.

J Neuroophthalmol 14(2), 77-80. Abstract
Strominger MB, Slamovits TL, Herskovitz S, et al. (1994)

https://www.unboundmedicine.com/medline ... e_disease_




In onderstaande pdf staan ook een aantal onderzoeken mbt Jarisch Herxheimer reactie en behandeling met anitiotica, als ik het goed heb gelezen komt het vaker voor bij mensen die met Cef worden behandeld dan mensen die met doxy worden behandeld:

https://pdfs.semanticscholar.org/0b3a/d ... cdacf8.pdf

Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Jarisch-Herxheimer reactie

Berichtdoor Henriëtte » Wo 02 Jan 2019, 18:21

Jarisch-Herxheimer and Lyme disease;

When patients diagnosed with chronic Lyme are treated, no matter what happens as a response to the treatment is considered by believers to be evidence in support of the diagnosis. If they get better, then that is evidence that the treatment is working. If they get worse, then that is evidence that the treatment is working and they are experiencing the JHR (or “herxing” as the community calls it). If nothing happens, they just need more treatment. No matter what happens or doesn’t happen, it’s chronic Lyme.
Steven Novella on October 25, 2017


the JHR was first described by Austrian dermatologist Adolf Jarisch (1895) and German dermatologist Karl Herxheimer (1902). They described a reaction to mercury in treating syphilis, in which the patients would have an exacerbation of their symptoms beginning 1-3 hours after treatment, lasting for about a day. Jarisch hypothesized that the mercury was killing off the syphilis spirochetes in large numbers, and the lysed bacteria were releasing endotoxins which were causing the symptoms.


The reaction, it has recently be discovered, is caused more by nonendotoxin pyrogen and spirochetal lipoproteins which stimulate the immune system, including inflammatory cytokines and tumor necrosis factor. The reaction has also been observed in Lyme disease, which is also caused by a spirochete, and in several other bacterial infections.


https://sciencebasedmedicine.org/jarisc ... e-disease/
Henriëtte

Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Jarisch-Herxheimer reactie

Berichtdoor Henriëtte » Do 23 Mei 2019, 08:31

Jarisch Herxheimer reactie bij Lyme ziekte; 18-11-1987 :geek:

Ofschoon de pathogenese nog altijd onbekend is, lijkt de reactie specifiek te zijn voor infecties met spirocheten, want ook bij Lyme-ziekte is dit verschijnsel waargenomen

https://www.ntvg.nl/artikelen/de-jarisc ... e/volledig

Henriëtte

Henriëtte
Berichten: 1598
Lid geworden op: Di 19 Mei 2015, 10:05

Re: Jarisch-Herxheimer reactie

Berichtdoor Henriëtte » Do 23 Mei 2019, 08:48

Jarisch Herxheimer Reaktion;

Die Herxheimer-Reaktion (auch Jarisch-Herxheimer-Reaktion genannt oder kurz Herx) ist eine bis zu mehreren Tagen andauernde Reaktion des Körpers auf Bakteriengifte (Endotoxine), die durch den therapiebedingten Zerfall einer großen Menge von Erregern entstehen und zur Freisetzung von Entzündungsbotenstoffen führen.[1]


Bei der Borreliose soll diese Reaktion bei etwa 30 bis 60 % der Patienten auftreten,


Typische Symptome sind plötzliches Fieber (auch mit Schüttelfrost) sowie eine Verschlimmerung der Symptome der ursprünglichen Infektionskrankheit (Allgemein- und Herdreaktionen). Im Prinzip können diese Symptome als ein Anzeichen der Wirksamkeit einer effektiven Therapie angesehen werden.


Als Prophylaxe können Kortisongaben sowie andere Maßnahmen (vermehrtes Trinken, Bäder) die Symptome günstig beeinflussen. Die Akutbehandlung besteht in der Verabreichung von 50–100 mg Prednison intravenös.[3] Kortison sollte allerdings bei einem Verdacht auf Borreliose auf keinen Fall gegeben werden


https://de.wikipedia.org/wiki/Jarisch-H ... r-Reaktion

Henriëtte


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